Cochliodone A
Product Specifications
UNSPSC Description
Cochliodone A is an active compound extracted from cultures of the deep-sea derived fungus Chaetomium sp. and has antibacterial and anticancer activity. Cochliodone A is toxic to a variety of bacteria, with MICs of 15.3 μg/mL (V. vulnificus), 32.7 μg/mL (V. rotiferianus), 15.9 μg/mL (S. aureus ATCC 43300), and 16.3 μg/mL (S . aureus CGMCC 1.12409). Cochliodone A also inhibits a variety of cancer cell lines, with IC50s of 28.1 μM (A549), 20.7 μM (HeLa), and 23.2 μM (Hep G2)[1].
Target Antigen
Bacterial
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/cochliodone-a.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CO[C@@]2(CCC[C@@H](C)O2)CC1=C3C(C([C@@](OC(C)=O)(C)C4=O)=O)=C5C4=CO[C@]6(O[C@H](C)CCC6)C5)[C@](C)(OC(C)=O)C3=O
Molecular Weight
638.66
References & Citations
[1]Wang W, et al. Chlorinated Azaphilone Pigments with Antimicrobial and Cytotoxic Activities Isolated from the Deep Sea Derived Fungus Chaetomium sp. NA-S01-R1. Mar Drugs. 2018 Feb 13;16(2):61..
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-115407/Cochliodone-A-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-115407/
Clinical Information
No Development Reported
CAS Number
1072931-48-6
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