GSK1521498 (free base) (hydrochloride)

GSK1521498 free base (hydrochloride) is a potent and selective μ-opioid receptor (MOR) antagonist. GSK1521498 free base (hydrochloride) is being used for the treatment of disorders of compulsive consumption of food, alcohol, and agents[1].

Product Specifications

CAS Number

[1007578-24-6]

UNSPSC

12352005

Hazard Statement

H302

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gsk1521498-free-base-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

FC1=C(CNC2CC3=C(C=CC=C3)C2)C(F)=CC(C4=CC=CC(C5=NC=NN5)=C4)=C1.[H]Cl

Molecular Formula

C24H21ClF2N4

Molecular Weight

438.90

Precautions

P264-P270-P330-P501

References & Citations

[1]Giuliano C, et al. The Novel μ-Opioid Receptor Antagonist GSK1521498 Decreases Both Alcohol Seeking and Drinking: Evidence from a New Preclinical Model of Alcohol Seeking. Neuropsychopharmacology. 2015 Dec;40 (13) :2981-92.