PGE-M
PGE-M is a metabolite of prostaglandin E2 (PEG2) as a biomarker of inflammation and cancer including advanced colorectal neoplasia, ovarian cancer, prostate cancer and so on. Urinary PGE-M is positively associated with obesity, smoking and lung metastases with breast cancer[1][2][3].
Product Specifications
CAS Number
24769-56-0
Product Name Alternative
Tetranor-PGEM
UNSPSC
12352211
Hazard Statement
H225, H319, H336
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pge-m.html
Concentration
304.54 μM * 250 μL in Methyl acetate
Purity
99.9
Solubility
10 mM in DMSO
Smiles
O[C@H]1[C@@H]([C@H](C(C1)=O)CCC(O)=O)CCC(CCCCC(O)=O)=O
Molecular Formula
C16H24O7
Molecular Weight
328.36
Precautions
H225, H319, H336
References & Citations
[1]Johnson JC, et al. Urine PGE-M: A metabolite of prostaglandin E2 as a potential biomarker of advanced colorectal neoplasia. Clin Gastroenterol Hepatol. 2006 Nov;4 (11) :1358-65.|[2]Wang D, DuBois RN. Urinary PGE-M: a promising cancer biomarker. Cancer Prev Res (Phila) . 2013 Jun;6 (6) :507-10.|[3]Morris PG, et al. Increased levels of urinary PGE-M, a biomarker of inflammation, occur in association with obesity, aging, and lung metastases in patients with breast cancer. Cancer Prev Res (Phila) . 2013 May;6 (5) :428-36.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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