SRTCX1002

SRTCX1002 is a potent activator of SIRT1 (STAC), suppresses inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB Activity. SRTCX1002 suppresses stimuli-induced NF-κB transcriptional activation and LPS-induced TNFα secretion with IC50s of 0.71 and 7.58 µM, respectively[1].

Product Specifications

CAS Number

1203479-63-3

UNSPSC

12352005

Target

Sirtuin

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

COVID-19-anti-virus

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/srtcx1002.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=NC=CS1)C2=C3NC(C4=CC=CC(N5CCOCC5)=C4)=NC3=CC=C2

Molecular Formula

C21H19N5O2S

Molecular Weight

405.47

References & Citations

[1]Hongying Yang, et al. SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity. PLoS One. 2012;7 (9) :e46364.