(E/Z) -BIO-acetoxime
(E/Z) -BIO-acetoxime (GSK-3 Inhibitor X) is a potent and selective GSK-3α/β inhibitor, with an IC50 of 10 nM. (E/Z) -BIO-acetoxime shows more than 200-flod selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B (IC50=2.4, 4.3, 63 μM) [1].
Product Specifications
CAS Number
740841-15-0
Product Name Alternative
GSK-3 Inhibitor X
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
CDK; GSK-3
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/e-z-bio-acetoxime.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
CC(O/N=C1/C(NC2=C1C=CC=C2)=C3C(NC4=C\3C=CC(Br)=C4)=O)=O
Molecular Formula
C18H12BrN3O3
Molecular Weight
398.21
Precautions
H302, H315, H319, H335
References & Citations
[1]Meijer L, et, al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol. 2003 Dec;10 (12) :1255-66.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK2; CDK5; GSK-3α; GSK-3β
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