(E/Z) -BIO-acetoxime

(E/Z) -BIO-acetoxime (GSK-3 Inhibitor X) is a potent and selective GSK-3α/β inhibitor, with an IC50 of 10 nM. (E/Z) -BIO-acetoxime shows more than 200-flod selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B (IC50=2.4, 4.3, 63 μM) [1].

Product Specifications

CAS Number

[740841-15-0]

Product Name Alternative

GSK-3 Inhibitor X

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CDK; GSK-3

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/e-z-bio-acetoxime.html

Purity

99.0

Solubility

10 mM in DMSO

Smiles

CC(O/N=C1/C(NC2=C1C=CC=C2)=C3C(NC4=C\3C=CC(Br)=C4)=O)=O

Molecular Formula

C18H12BrN3O3

Molecular Weight

398.21

Precautions

H302, H315, H319, H335

References & Citations

[1]Meijer L, et, al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol. 2003 Dec;10 (12) :1255-66.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK1; CDK2; CDK5; GSK-3α; GSK-3β

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