Homocarnosine

Homocarnosine is a dipeptide of γ-aminobutyric acid (GABA) and histidine unique to brain. Homocarnosine is an inhibitory neuromodulator synthesized in the neuron from GABA and exhibiting anticonvulsant effects[1].Homocarnosine has antioxidant and anti-inflammatory actions, prevention of DNA damage, and inhibition of advanced glycation end-product formation[2].

Product Specifications

CAS Number

[3650-73-5]

Product Name Alternative

L-Homocarnosine

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Endogenous Metabolite; GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/homocarnosine.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](NC(CCCN)=O)CC1=CNC=N1)O

Molecular Formula

C10H16N4O3

Molecular Weight

240.26

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]O A Petroff, et al. Vigabatrin increases human brain homocarnosine and improves seizure control. Ann Neurol. 1998 Dec;44 (6) :948-52.|[2]Thanutchaporn Kumrungsee, et al. Dietary GABA induces endogenous synthesis of a novel imidazole peptide homocarnosine in mouse skeletal muscles. Amino Acids. 2020 May;52 (5) :743-753.