SL651498

SL651498 is a full agonist of α2 and α3 GABAA receptors, and a partial agonist of α1 and α5 GABAA receptors. SL651498 shows anxiolytic and anticonvulsant activities[1].

Product Specifications

CAS Number

[205881-86-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/sl651498.html

Purity

98.2

Solubility

DMSO : 38.9 mg/mL (ultrasonic; warming)

Smiles

O=C(C1=CN(C(C2=C1C3=C(C=CC(F)=C3)N2C)=O)C4=CC=CC=C4)N5CCCC5

Molecular Formula

C23H20FN3O2

Molecular Weight

389.42

Precautions

H302, H315, H319, H335

References & Citations

[1]G Griebel, et al. SL651498: an anxioselective compound with functional selectivity for alpha2- and alpha3-containing gamma-aminobutyric acid (A) (GABA (A) ) receptors. J Pharmacol Exp Ther. 2001 Aug;298 (2) :753-68.