Eritadenine

Eritadenine (D-Eritadenine) is a potent AdoHcyase inhibitor, with an IC50 value of 7 nM. Eritadenine is also an acyclic sugar adenosine analogue. Eritadenine exhibits an inhibitory effect on the growth of Cryptosporidium parvum, with a MIC50 of 3 μM. Eritadenine can be used in the research of colorectal adenocarcinoma[1][2].

Product Specifications

CAS Number

[23918-98-1]

Product Name Alternative

Lentinacin; D-Eritadenine; Lentysine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Nucleoside Antimetabolite/Analog; Parasite

Type

Natural Products

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

Neuroscience-Neuromodulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/eritadenine.html

Purity

97.9

Solubility

10 mM in DMSO

Smiles

O=C([C@@H]([C@@H](CN1C=NC2=C(N=CN=C12)N)O)O)O

Molecular Formula

C9H11N5O4

Molecular Weight

253.21

Precautions

H302, H315, H319, H335

References & Citations

[1]Huang Y, et al. Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine. J Biol Chem. 2002 Mar 1;277 (9) :7477-82. |[2]Ctrnáctá V, et al. Efficacy of S-adenosylhomocysteine hydrolase inhibitors, D-eritadenine and (S) -DHPA, against the growth of Cryptosporidium parvum in vitro. Exp Parasitol. 2010 Oct;126 (2) :113-6.