Ro 22-9194

Ro 22-9194 inhibits aggregation and thromboxane Az (TXA2) synthetase activity in rabbit and human platelets. Ro 22-9194 has a potent inhibitory action against various types of model arrhythmias. Ro 22-9194 has non-cholinergic cardiac depressant properties with its vasodilating action[1][2].

Product Specifications

CAS Number

[106134-33-2]

UNSPSC

12352005

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ro-22-9194.html

Solubility

10 mM in DMSO

Smiles

CC(N)C(N(C1=C(C)C=CC=C1C)CCCC2=CC=CN=C2)=O.[H]Cl.[H]Cl

Molecular Formula

C19H27Cl2N3O

Molecular Weight

384.34

References & Citations

[1]M Murakami, et al. Cardiovascular effects of 2-amino-N- (2,6-dimethylphenyl) -N-[3- (3-pyridyl) propyl]propionamide dihydrochloride (Ro 22-9194) in the isolated, cross-perfused atrium of the dog. Jpn Heart J. 1990 Sep;31 (5) :731-9.|[2]I Kodama, et al. Electropharmacology of Ro 22-9194, a new antiarrhythmic agent. Gen Pharmacol. 1996 Jul;27 (5) :755-60.