Ro 22-9194
Ro 22-9194 inhibits aggregation and thromboxane Az (TXA2) synthetase activity in rabbit and human platelets. Ro 22-9194 has a potent inhibitory action against various types of model arrhythmias. Ro 22-9194 has non-cholinergic cardiac depressant properties with its vasodilating action[1][2].
Product Specifications
CAS Number
106134-33-2
UNSPSC
12352005
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ro-22-9194.html
Solubility
10 mM in DMSO
Smiles
CC(N)C(N(C1=C(C)C=CC=C1C)CCCC2=CC=CN=C2)=O.[H]Cl.[H]Cl
Molecular Formula
C19H27Cl2N3O
Molecular Weight
384.34
References & Citations
[1]M Murakami, et al. Cardiovascular effects of 2-amino-N- (2,6-dimethylphenyl) -N-[3- (3-pyridyl) propyl]propionamide dihydrochloride (Ro 22-9194) in the isolated, cross-perfused atrium of the dog. Jpn Heart J. 1990 Sep;31 (5) :731-9.|[2]I Kodama, et al. Electropharmacology of Ro 22-9194, a new antiarrhythmic agent. Gen Pharmacol. 1996 Jul;27 (5) :755-60.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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