ORM-10921 (free base)
ORM-10921 free base is a selective α-2C adrenergic receptor antagonist with a Ki of 1.4 nM. ORM-10921 free base displays potent antidepressant and antipsychotic-like effects[1].
Product Specifications
CAS Number
[610782-82-6]
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/orm-10921-free-base.html
Purity
98.08
Solubility
10 mM in DMSO
Smiles
C[C@@]1(CCCN2CCC3=C([C@]12[H])OC4=CC=CC=C43)COC
Molecular Formula
C18H23NO2
Molecular Weight
285.38
References & Citations
[1]Jukka Sallinen, et al. Pharmacological characterisation of a structurally novel α2C-adrenoceptor antagonist ORM-10921 and its effects in neuropsychiatric models. Basic Clin Pharmacol Toxicol. 2013 Oct;113 (4) :239-49.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
α adrenergic receptor
Available Sizes
Curated Selection
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