KNK423
KNK423 is a specific heat shock protein (HSP) synthesis inhibitor. KNK423 improves the efficiency of Amphotericin B in inhibiting resistant Aspergillus terreus by blocking HSP70. KNK423 can be used in cancer and bacterial infection research[1][2].
Product Specifications
CAS Number
1859-42-3
UNSPSC
12352005
Hazard Statement
H315-H319
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/knk423.html
Solubility
10 mM in DMSO
Smiles
O=C1NCC/C1=C\C2=CC=C3OCOC3=C2
Molecular Formula
C12H11NO3
Molecular Weight
217.22
Precautions
P264-P280-P302+P352-P362+P364
References & Citations
[1]Koishi M, et al. The effects of KNK437, a novel inhibitor of heat shock protein synthesis, on the acquisition of thermotolerance in a murine transplantable tumor in vivo. Clin Cancer Res. 2001 Jan;7 (1) :215-9.|[2]Blatzer M, et al. Blocking Hsp70 enhances the efficiency of amphotericin B treatment against resistant Aspergillus terreus strains. Antimicrob Agents Chemother. 2015 Jul;59 (7) :3778-88.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
orb2398521 100 µL
Serca2/SERCA2 ATPase Rabbit Polyclonal Antibody (PerCP-Cy5.5)
Sign In for Pricing
View Details 
454709-02 100 mg
Methyl 2- (1H-Imidazol-4-yl) acetate Hydrochloride
Sign In for Pricing
View Details 364830 200 µL
PTTG1IP (Pituitary Tumor Transforming 1 Interacting Protein, PBF, C21orf1, C21orf3, Pituitary tumor-transforming gene protein-binding factor)
Sign In for Pricing
View Details