KNK423

KNK423 is a specific heat shock protein (HSP) synthesis inhibitor. KNK423 improves the efficiency of Amphotericin B in inhibiting resistant Aspergillus terreus by blocking HSP70. KNK423 can be used in cancer and bacterial infection research[1][2].

Product Specifications

CAS Number

[1859-42-3]

UNSPSC

12352005

Hazard Statement

H315-H319

Target

HSP

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/knk423.html

Solubility

10 mM in DMSO

Smiles

O=C1NCC/C1=C\C2=CC=C3OCOC3=C2

Molecular Formula

C12H11NO3

Molecular Weight

217.22

Precautions

P264-P280-P302+P352-P362+P364

References & Citations

[1]Koishi M, et al. The effects of KNK437, a novel inhibitor of heat shock protein synthesis, on the acquisition of thermotolerance in a murine transplantable tumor in vivo. Clin Cancer Res. 2001 Jan;7 (1) :215-9.|[2]Blatzer M, et al. Blocking Hsp70 enhances the efficiency of amphotericin B treatment against resistant Aspergillus terreus strains. Antimicrob Agents Chemother. 2015 Jul;59 (7) :3778-88.