Mesoxalate

Mesoxalate (Ketomalonic acid) a dicarboxylic acid and a ketonic acid which blocks HIV-1 reverse transcriptase (RT), with the IC50 of 2.2 μM[1][2].

Product Specifications

CAS Number

473-90-5

Product Name Alternative

Ketomalonic acid; Mesoxalic acid; Oxomalonic acid

UNSPSC

12352211

Hazard Statement

H302-H315-H318-H335

Target

HIV

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ketomalonic-acid.html

Solubility

10 mM in DMSO

Smiles

O=C(C(C(O)=O)=O)O

Molecular Formula

C3H2O5

Molecular Weight

118.04

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Jean A Bernatchez, et al. Derivatives of mesoxalic acid block translocation of HIV-1 reverse transcriptase. J Biol Chem. 2015 Jan 16;290 (3) :1474-84.|[2]W R Davis, et al. Inhibition of HIV-1 reverse transcriptase-catalyzed DNA strand transfer reactions by 4-chlorophenylhydrazone of mesoxalic acid. Biochemistry. 2000 Nov 21;39 (46) :14279-91.