AMP-Deoxynojirimycin
AMP-Deoxynojirimycin (AMP-DNM) is a potent ceramide glucosyltransferase and GCase 2 inhibitor. AMP-Deoxynojirimycin also is a GlcCer biosynthesis inhibitor[1][2].
Product Specifications
CAS Number
216758-20-2
Product Name Alternative
AMP-DNM
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Glucosylceramide Synthase (GCS) ; Glycosidase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/amp-deoxynojirimycin.html
Purity
99.7
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC[C@H]([C@H]([C@@H]1O)O)N(C[C@@H]1O)CCCCCOCC2(C[C@H](C3)C4)C[C@H]4C[C@H]3C2
Molecular Formula
C22H39NO5
Molecular Weight
397.55
Precautions
H302, H315, H319
References & Citations
[1]Zhu M, et al. Monomethyl branched-chain fatty acid mediates amino acid sensing upstream of mTORC1. Dev Cell. 2021 Oct 11;56 (19) :2692-2702.e5.|[2]Bae EJ, et al. Loss of glucocerebrosidase 1 activity causes lysosomal dysfunction and α-synuclein aggregation. Exp Mol Med. 2015 Mar 27;47 (3) :e153.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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