AMP-Deoxynojirimycin

AMP-Deoxynojirimycin (AMP-DNM) is a potent ceramide glucosyltransferase and GCase 2 inhibitor. AMP-Deoxynojirimycin also is a GlcCer biosynthesis inhibitor[1][2].

Product Specifications

CAS Number

[216758-20-2]

Product Name Alternative

AMP-DNM

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Glucosylceramide Synthase (GCS) ; Glycosidase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/amp-deoxynojirimycin.html

Purity

99.7

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC[C@H]([C@H]([C@@H]1O)O)N(C[C@@H]1O)CCCCCOCC2(C[C@H](C3)C4)C[C@H]4C[C@H]3C2

Molecular Formula

C22H39NO5

Molecular Weight

397.55

Precautions

H302, H315, H319

References & Citations

[1]Zhu M, et al. Monomethyl branched-chain fatty acid mediates amino acid sensing upstream of mTORC1. Dev Cell. 2021 Oct 11;56 (19) :2692-2702.e5.|[2]Bae EJ, et al. Loss of glucocerebrosidase 1 activity causes lysosomal dysfunction and α-synuclein aggregation. Exp Mol Med. 2015 Mar 27;47 (3) :e153.