(E) -4-Oxo-2-nonenal
(E) -4-Oxo-2-nonenal (4-ONE) is one of the major hemolytic decomposition products of lipid hydroperoxides. (E) -4-Oxo-2-nonenal is a major product of the FeII-mediated breakdown of lipid hydroperoxides. (E) -4-Oxo-2-nonenal is a potent transient receptor potential ankyrin 1 (TRPA1) agonist[1][2][3].
Product Specifications
CAS Number
103560-62-9
Product Name Alternative
4-ONE
UNSPSC
12352211
Hazard Statement
H225, H319, H336
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/e-4-oxo-2-nonenal.html
Purity
95.0
Solubility
10 mM in DMSO
Smiles
O=C/C=C/C(CCCCC)=O
Molecular Formula
C9H14O2
Molecular Weight
154.21
Precautions
H225, H319, H336
References & Citations
[1]S H Lee, et al. Characterization of 4-oxo-2-nonenal as a novel product of lipid peroxidation. Chem Res Toxicol. 2000 Aug;13 (8) :698-702.|[2]Fumie Saito, et al. Reaction products of gamma-tocopherol with (E) -4-oxo-2-nonenal in acidic acetonitrile. Biosci Biotechnol Biochem. 2010;74 (1) :168-74.|[3]Rabea Graepel, et al. 4-oxo-2-nonenal (4-ONE) : evidence of transient receptor potential ankyrin 1-dependent and -independent nociceptive and vasoactive responses in vivo. J Pharmacol Exp Ther. 2011 Apr;337 (1) :117-24.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
PKSV030248 100 µg
Recombinant SARS-CoV Nucleoprotein / NP Protein (His Tag)
Sign In for Pricing
View Details 
