(E) -4-Oxo-2-nonenal
(E) -4-Oxo-2-nonenal (4-ONE) is one of the major hemolytic decomposition products of lipid hydroperoxides. (E) -4-Oxo-2-nonenal is a major product of the FeII-mediated breakdown of lipid hydroperoxides. (E) -4-Oxo-2-nonenal is a potent transient receptor potential ankyrin 1 (TRPA1) agonist[1][2][3].
Product Specifications
CAS Number
103560-62-9
Product Name Alternative
4-ONE
UNSPSC
12352211
Hazard Statement
H225, H319, H336
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/e-4-oxo-2-nonenal.html
Purity
95.0
Solubility
10 mM in DMSO
Smiles
O=C/C=C/C(CCCCC)=O
Molecular Formula
C9H14O2
Molecular Weight
154.21
Precautions
H225, H319, H336
References & Citations
[1]S H Lee, et al. Characterization of 4-oxo-2-nonenal as a novel product of lipid peroxidation. Chem Res Toxicol. 2000 Aug;13 (8) :698-702.|[2]Fumie Saito, et al. Reaction products of gamma-tocopherol with (E) -4-oxo-2-nonenal in acidic acetonitrile. Biosci Biotechnol Biochem. 2010;74 (1) :168-74.|[3]Rabea Graepel, et al. 4-oxo-2-nonenal (4-ONE) : evidence of transient receptor potential ankyrin 1-dependent and -independent nociceptive and vasoactive responses in vivo. J Pharmacol Exp Ther. 2011 Apr;337 (1) :117-24.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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