(E) -4-Oxo-2-nonenal

(E) -4-Oxo-2-nonenal (4-ONE) is one of the major hemolytic decomposition products of lipid hydroperoxides. (E) -4-Oxo-2-nonenal is a major product of the FeII-mediated breakdown of lipid hydroperoxides. (E) -4-Oxo-2-nonenal is a potent transient receptor potential ankyrin 1 (TRPA1) agonist[1][2][3].

Product Specifications

CAS Number

[103560-62-9]

Product Name Alternative

4-ONE

UNSPSC

12352211

Hazard Statement

H225, H319, H336

Target

TRP Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/e-4-oxo-2-nonenal.html

Purity

95.0

Solubility

10 mM in DMSO

Smiles

O=C/C=C/C(CCCCC)=O

Molecular Formula

C9H14O2

Molecular Weight

154.21

Precautions

H225, H319, H336

References & Citations

[1]S H Lee, et al. Characterization of 4-oxo-2-nonenal as a novel product of lipid peroxidation. Chem Res Toxicol. 2000 Aug;13 (8) :698-702.|[2]Fumie Saito, et al. Reaction products of gamma-tocopherol with (E) -4-oxo-2-nonenal in acidic acetonitrile. Biosci Biotechnol Biochem. 2010;74 (1) :168-74.|[3]Rabea Graepel, et al. 4-oxo-2-nonenal (4-ONE) : evidence of transient receptor potential ankyrin 1-dependent and -independent nociceptive and vasoactive responses in vivo. J Pharmacol Exp Ther. 2011 Apr;337 (1) :117-24.