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(E/Z) -NSAH

(E/Z) -NSAH is an isoform of NSAH , which is reversible and competitive nonnucleoside ribonucleotide reductase (RR) inhibitor, with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively[1].

Product Specifications

CAS Number

54009-54-0

UNSPSC

12352005

Hazard Statement

H302-H319-H372-H410

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e-z-nsah.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=CC=C1O)N/N=C/C2=C3C=CC=CC3=CC=C2O

Molecular Formula

C18H14N2O3

Molecular Weight

306.32

Precautions

P260-P264-P270-P273-P280-P305+P351+P338-P330-P391-P501

References & Citations

[1]Md Faiz Ahmad, et al. Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proc Natl Acad Sci U S A. 2017 Aug 1;114 (31) :8241-8246.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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