(E/Z) -NSAH
(E/Z) -NSAH is an isoform of NSAH , which is reversible and competitive nonnucleoside ribonucleotide reductase (RR) inhibitor, with cell-free IC50 of 32 μM and cell-based IC50 of ~250 nM, respectively[1].
Product Specifications
CAS Number
54009-54-0
UNSPSC
12352005
Hazard Statement
H302-H319-H372-H410
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e-z-nsah.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC=C1O)N/N=C/C2=C3C=CC=CC3=CC=C2O
Molecular Formula
C18H14N2O3
Molecular Weight
306.32
Precautions
P260-P264-P270-P273-P280-P305+P351+P338-P330-P391-P501
References & Citations
[1]Md Faiz Ahmad, et al. Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proc Natl Acad Sci U S A. 2017 Aug 1;114 (31) :8241-8246.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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