MRTX-1257-d6
MRTX-1257-d6 is the deuterium labeled MRTX-1257. MRTX-1257 is a selective, irreversible, covalent and orally active KRAS G12C inhibitor, with an IC50 of 900 pM for KRAS dependent ERK phosphorylation in H358 cells[1][2].
Product Specifications
CAS Number
2639608-44-7
UNSPSC
12352005
Target
Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
[2H]C([2H])([2H])N(CCC1)[C@@H]1COC2=NC(N3C[C@@H](N(CC3)C(C=C)=O)CC#N)=C4C(CN(C5=CC=CC6=C5C(C([2H])([2H])[2H])=CC=C6)CC4)=N2
Molecular Formula
C33H33D6N7O2
Molecular Weight
571.75
References & Citations
[1]Matthew et al. Structure-Based Drug Discovery of MRTX1257, a Selective, Covalent KRAS G12C Inhibitor with Oral Activity in Animal Models of Cancer.|[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-220.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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