H-Ile-Pro-Pro-OH

H-Ile-Pro-Pro-OH, a milk-derived peptide[1], inhibits angiotensin-converting enzyme (ACE) [1] with an IC50 of 5 μM[2]. Antihypertensive tripeptides[1].

Product Specifications

CAS Number

[26001-32-1]

UNSPSC

12352209

Hazard Statement

H302-H315-H319

Target

Angiotensin-converting Enzyme (ACE)

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/H-Ile-Pro-Pro-OH.html

Solubility

10 mM in DMSO

Smiles

O=C(N1[C@@H](CCC1)C(N2[C@@H](CCC2)C(O)=O)=O)[C@H]([C@@H](C)CC)N

Molecular Formula

C16H27N3O4

Molecular Weight

325.40

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501

References & Citations

[1]Nonaka A, et al. The milk-derived peptides Val-Pro-Pro and Ile-Pro-Pro attenuate arterial dysfunction in L-NAME-treated rats. Hypertens Res. 2014 Aug;37 (8) :703-7.|[2]Nakamura Y, et al. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci. 1995 Apr;78 (4) :777-83.