SJFδ
SJFδ is a 10-atom linker PROTAC based on von Hippel-Lindau ligand. SJFδ degrades p38δ with a DC50 of 46.17 nM, but does not degrade p38α, p38β, or p38γ[1].
Product Specifications
CAS Number
[2254609-23-7]
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Autophagy; p38 MAPK; PROTACs
Type
Reference compound
Related Pathways
Autophagy; MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/SJF_delta_.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=C(NC(C2(CC2)C(NC3=CC(F)=C(OC4=C(C=C(OC)C(OCCOCCOCCOC5=CC(C6=C(C)N=CS6)=CC=C5CNC([C@@H]7C[C@@H](O)CN7C([C@@H](N8C(C9=CC=CC=C9C8)=O)C(C)C)=O)=O)=C%10)C%10=NC=C4)C=C3)=O)=O)C=C1
Molecular Formula
C62H63F2N7O12S
Molecular Weight
1168.27
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Smith BE, et al. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat Commun. 2019 Jan 10;10 (1) :131.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P38α; von Hippel-Lindau (VHL)
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