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SJFδ

SJFδ is a 10-atom linker PROTAC based on von Hippel-Lindau ligand. SJFδ degrades p38δ with a DC50 of 46.17 nM, but does not degrade p38α, p38β, or p38γ[1].

Product Specifications

CAS Number

[2254609-23-7]

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Autophagy; p38 MAPK; PROTACs

Type

Reference compound

Related Pathways

Autophagy; MAPK/ERK Pathway; PROTAC

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/SJF_delta_.html

Solubility

10 mM in DMSO

Smiles

FC1=CC=C(NC(C2(CC2)C(NC3=CC(F)=C(OC4=C(C=C(OC)C(OCCOCCOCCOC5=CC(C6=C(C)N=CS6)=CC=C5CNC([C@@H]7C[C@@H](O)CN7C([C@@H](N8C(C9=CC=CC=C9C8)=O)C(C)C)=O)=O)=C%10)C%10=NC=C4)C=C3)=O)=O)C=C1

Molecular Formula

C62H63F2N7O12S

Molecular Weight

1168.27

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Smith BE, et al. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nat Commun. 2019 Jan 10;10 (1) :131.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-114405/SJFδ-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-114405/

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

P38α; von Hippel-Lindau (VHL)

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