BuChE-IN-TM-10
BuChE-IN-TM-10 (TM-10) is a potent butyrylcholinesterase (BuChE) inhibitor, with an IC50 of 8.9 nM. BuChE inhibitor 1 inhibits and disaggregates self-induced Aβ aggregation, exhibiting potent antioxidant activity and good blood-brain barrier (BBB) penetration. Has potential to treat Alzheimer’s disease[1].
Product Specifications
CAS Number
2313524-95-5
Product Name Alternative
TM-10
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/buche-in-tm-10.html
Solubility
10 mM in DMSO
Smiles
O=C(N1CC2=C(C=CC=C2)CC1)/C=C/C3=CC=C(OCCCCN(CC4=CC=CC=C4)CC)C(OC)=C3
Molecular Formula
C32H38N2O3
Molecular Weight
498.66
References & Citations
[1]Sang Z, et al. Design, Synthesis, and Evaluation of Novel Ferulic Acid Derivatives as Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease. ACS Chem Neurosci. 2019 Feb 20;10 (2) :1008-1024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC400701-100 1x 100 µL
Melanoma Marker (HMB45 + M2-7C10 + M2-9E3 + T311), CF640R conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
![Elab Bright™ Violet 421 Rat IgG1, κ Isotype Control[R3-34]](https://cdn.genprice.uk/products/763/689dc1c161c8d595fe2fc98b/imageurl/an00820q2.webp)
AN00820Q2 20 Tests
Elab Bright™ Violet 421 Rat IgG1, κ Isotype Control[R3-34]
Sign In for Pricing
View Details 
TRC-T774355-25MG 25 mg
2-((2,3,4-Trichloro-6-nitrobenzyl)amino)acetic Acid Ethyl Ester
Sign In for Pricing
View Details