DL-3-Hydroxy-3-methylglutaryl coenzyme A (disodium hydrate)

DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium hydrate is a disodium salt compound of HMG-CoA, is a intermediate of terpenes and ketone bodies. DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium also involves in ester metabolism in vivo, as a precursor for cholesterol synthesis, and regulates cholesterol synthesis by coupling LDL receptor[1][2].

Product Specifications

CAS Number

[103476-21-7]

Product Name Alternative

HMG-CoA (disodium hydrate)

UNSPSC

12352204

Hazard Statement

H302, H315, H319, H335

Target

Biochemical Assay Reagents

Type

Biochemical Assay Reagents

Related Pathways

Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/dl-3-hydroxy-3-methylglutaryl-coenzyme-a-disodium.html

Purity

99.0

Solubility

H2O : 50 mg/mL (ultrasonic; warming)

Smiles

O[C@@H]1[C@H](OP(O)(O)=O)[C@H](O[C@H]1N2C(N=CN=C3N)=C3N=C2)COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CC(C)(O)CC(O)=O)=O)=O)=O)(O[Na])=O)(O[Na])=O.[x].O

Molecular Formula

C27H42N7Na2O20P3S.xH2O

Precautions

H302, H315, H319, H335

References & Citations

[1]Millán Núñez-Cortés J, et al. Fármacos hipolipemiantes y PCSK9 [Lipid-lowering drugs and PCSK9]. Clin Investig Arterioscler. 2016 May;28 Suppl 2:9-13. Spanish. |[2]Wang Wei, er al. The Key Enzyme of Cholesterol Synthesis Pathway:HMG CoA Reductase and Disease. PROGRESS IN PHYSIOLOGICAL SCIENCES. 1999. (01) :7-11.