Se-Methylselenocysteine (hydrochloride)

Se-Methylselenocysteine hydrochloride, a precursor of Methylselenol, has potent cancer chemopreventive activity and anti-oxidant activity. Se-Methylselenocysteine hydrochloride is orally bioavailable, and induces apoptosis[1][2].

Product Specifications

CAS Number

[863394-07-4]

Product Name Alternative

Methylselenocysteine (hydrochloride) ; Se-Methylseleno-L-cysteine (hydrochloride)

UNSPSC

12352211

Hazard Statement

H301-H331-H373-H410

Target

Apoptosis; Beta-secretase; Endogenous Metabolite

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/se-methylselenocysteine-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

C[Se]C[C@H](N)C(O)=O.Cl

Molecular Formula

C4H10ClNO2Se

Molecular Weight

218.54

Precautions

P261-P273-P501

References & Citations

[1]Yeo JK, et al. Se-methylselenocysteine induces apoptosis through caspase activation and Bax cleavage mediated by calpain in SKOV-3 ovarian cancer cells. Cancer Lett. 2002 Aug 8;182 (1) :83-92.|[2]Cao S, et al. Se-methylselenocysteine offers selective protection against toxicity and potentiates the antitumour activity of anticancer drugs in preclinical animal models. Br J Cancer. 2014 Apr 2;110 (7) :1733-43.|[3]Xie Y, et al. Se-Methylselenocysteine Ameliorates Neuropathology and Cognitive Deficits by Attenuating Oxidative Stress and Metal Dyshomeostasis in Alzheimer Model Mice. Mol Nutr Food Res. 2018 Jun;62 (12) :e1800107.