TAK-070 (Free base)
TAK-070 Free base is a noncompetitive and orally active BACE1 inhibitor (IC50: 3.15 μM) . TAK-070 Free base can be used for research of Alzheimer’s disease (AD) . TAK-070 Free base inhibits brain levels of soluble Aβ, and improves cognitive impairments in AD model[1].
Product Specifications
CAS Number
212571-56-7
UNSPSC
12352005
Target
Amyloid-β; Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tak-070-free-base.html
Solubility
10 mM in DMSO
Smiles
CN(CC[C@H]1CC2=C(CC1)C=C(C=C2)OCC3=CC=C(C=C3)C4=CC=CC=C4)C
Molecular Formula
C27H31NO
Molecular Weight
385.54
References & Citations
[1]Fukumoto H, et al. A noncompetitive BACE1 inhibitor TAK-070 ameliorates Abeta pathology and behavioral deficits in a mouse model of Alzheimer's disease. J Neurosci. 2010 Aug 18;30 (33) :11157-66.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BACE1
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