TP-238
TP-238 is a potent and selective dual CECR2/BPTF probe with IC50 values of 30 nM and 350 nM, respectively. TP-238 also inhibits BRD9 with a pIC50 of 5.9 and is less active against other 338 kinases[1][2].
Product Specifications
CAS Number
2415263-04-4
UNSPSC
12352005
Target
Epigenetic Reader Domain
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tp-238.html
Solubility
10 mM in DMSO
Smiles
CN(C)CCCOC1=CC=C(C=C1)C2=CC(NCCCN3N=CC=C3)=NC(S(=O)(C)=O)=N2
Molecular Formula
C22H30N6O3S
Molecular Weight
458.58
References & Citations
[1]Michael A Clegg, et al. Advancements in the Development of non-BET Bromodomain Chemical Probes. ChemMedChem. 2019 Feb 19;14 (4) :362-385.|[2]Peter D Ycas, et al. New Inhibitors for the BPTF Bromodomain Enabled by Structural Biology and Biophysical Assay Development. Org Biomol Chem. 2020 Jun 26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD9; CECR2
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
30558121 3x 1.0µg DNA
MRPS21P5 CRISPRa sgRNA lentivector (set of three targets)(Human)
Sign In for Pricing
View Details