SSTR5 antagonist 2

SSTR5 antagonist 2 (compound 10) is a highly potent, oral active and selective somatostatin (receptor) subtype 5 (SSTR5) antagonist and has potential for the research of treat type 2 diabetes mellitus (T2DM) [1].

Product Specifications

CAS Number

[1254730-81-8]

UNSPSC

12352005

Target

Somatostatin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Endocrinology

Assay Protocol

https://www.medchemexpress.com/sstr5-antagonist-2.html

Solubility

DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C)

Smiles

FC(C=C1)=CC=C1C2=C(OCC)C=C(CN3CCC4(CN(C5=CC=C(C(O)=O)C=C5)C(C4)=O)CC3)C=C2OCC

Molecular Formula

C32H35FN2O5

Molecular Weight

546.63

References & Citations

[1]Liu W, et al. Discovery and Pharmacology of a Novel Somatostatin Subtype 5 (SSTR5) Antagonist: Synergy with DPP-4 Inhibition. ACS Med Chem Lett. 2018 Sep 12;9 (11) :1082-1087.