Ep vinyl quinidine

Ep vinyl quinidine (3-Epiquinine) is an epi-vinyl stereoisomer of Quinidine. Quinidine is an antiarrhythmic agent. Quinidine is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine is also a K+ channel blocker with an IC50 of 19.9 μM. Quinidine can be used for malaria research[1][2][3].

Product Specifications

CAS Number

[101143-87-7]

Product Name Alternative

3-Epiquinine; Epivinylquinidine

UNSPSC

12352005

Hazard Statement

H315-H319-H320

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ep-vinyl-quinidine.html

Solubility

10 mM in DMSO

Smiles

O[C@H]([C@]1([H])[N@@]2C[C@H]([C@@H](CC2)C1)C=C)C3=CC=NC4=C3C=C(OC)C=C4

Molecular Formula

C20H24N2O2

Molecular Weight

324.42

Precautions

P264-P280-P302+P352-P305+P351+P338-P362

References & Citations

[1]Hu B, et al. Origin of and a Solution for Uneven Efficiency by Cinchona Alkaloid-Derived, Pseudoenantiomeric Catalysts for Asymmetric Reactions. J Am Chem Soc. 2018 Oct 24;140 (42) :13913-13920.|[2]Kehl SJ. Quinidine-induced inhibition of the fast transient outward K+ current in rat melanotrophs. Br J Pharmacol. 1991 Jul;103 (3) :1807-13.|[3]Roden DM, et al. Class I antiarrhythmic agents: quinidine, procainamide and N-acetylprocainamide, disopyramide. Pharmacol Ther. 1983;23 (2) :179-91.