CP-346086 (dihydrate)

CP-346086 dihydrate is a potent and orally active microsomal triglyceride transfer protein (MTP) inhibitor, with an IC50 of 2.0 nM for human and rodent MTP. CP-346086 dihydrate can lower plasma cholesterol and triglycerides in vivo[1].

Product Specifications

CAS Number

[1262769-98-1]

UNSPSC

12352005

Target

Microsomal Triglyceride Transfer Protein (MTP)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/cp-346086-dihydrate.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=CC=C1C2=CC=C(C(F)(F)F)C=C2)NC3=CC4=C(CN(CC5=NC=NN5)CC4)C=C3.[H]O[H].[H]O[H]

Molecular Formula

C26H26F3N5O3

Molecular Weight

513.51

References & Citations

[1]Chandler CE, et, al. CP-346086: an MTP inhibitor that lowers plasma cholesterol and triglycerides in experimental animals and in humans. J Lipid Res. 2003 Oct;44 (10) :1887-901.