A-943931

A-943931 is a potent and selective histamine H4 receptor (H4R) antagonist with pKi values of 4.6, 3.8 nM for human and rat H4R, respectively. A-943931 shows anti-inflammatory and antinociceptive efficacy[1][2].

Product Specifications

CAS Number

[1027330-97-7]

UNSPSC

12352005

Target

Histamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/a-943931.html

Purity

99.57

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

N[C@@H](C1)CCN1C2=C3CCCC4=CC=CC=C4C3=NC(N)=N2

Molecular Formula

C17H21N5

Molecular Weight

295.38

References & Citations

[1]Ivan Milicic, et al. Identification of two potent and selective histamine H4 receptor antagonists with antipruritic activity. The FASEB journal homepage. 2009.|[2]Cowart MD, et al. Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models. J Med Chem. 2008 Oct 23;51 (20) :6547-57.