Kuguaglycoside C

Kuguaglycoside C is a triterpene glycoside that can be isolated from the leaves of Momordica charantia. Kuguaglycoside C induces caspase‐independent DNA cleavage and cell death of neuroblastoma cells. Kuguaglycoside C also significantly increases the expression and cleavage of apoptosis-inducing factor (AIF)[1].

C=C(C)/C=C/C[C@@H](C)[C@@]1([H])CC[C@@]([C@]1(C)CC2)(C)[C@]([C@]2(C=O)[C@@](CC[C@H](O)C3(C)C)([H])C3=C4)([H])[C@H]4O[C@]5([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O

[1]Tabata K, et al. Kuguaglycoside C, a constituent of Momordica charantia, induces caspase-independent cell death of neuroblastoma cells. Cancer Sci. 2012 Dec;103(12):2153-8.