12 (S) -HPEPE

12 (S) -HPEPE is a lipoxygenase product and an intermediate metabolite that leads to downregulation of PGHS-2 and has potential anti-inflammatory activity. 12 (S) -HPEPE reduces interleukin 1h (IL-1h) -induced PGHS-2 expression in human lung microvascular endothelial cells[1].

Product Specifications

CAS Number

[103239-14-1]

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Prostaglandin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/12-s-hpepe.html

Solubility

10 mM in DMSO

Smiles

CC/C=C\C/C=C\C[C@H](OO)/C=C/C=C\C/C=C\CCCC(O)=O

Molecular Formula

C20H30O4

Molecular Weight

334.45

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Ait-Said F, et al. Inhibition by eicosapentaenoic acid of IL-1beta-induced PGHS-2 expression in human microvascular endothelial cells: involvement of lipoxygenase-derived metabolites and p38 MAPK pathway. Biochim Biophys Acta. 2003 Feb 20;1631 (1) :77-84.