β-Interleukin I (163-171), human

β-Interleukin I (163-171), human, an immunostimulatory fragment of human IL-1β peptide, is a T cell activator. β-Interleukin I (163-171), human is not an IL-1R-binding domain of IL-1β. β-Interleukin I (163-171), human is a potent adjuvant that enhances the immune response in a variety of exptl. situations[1][3][4].

Product Specifications

CAS Number

[106021-96-9]

UNSPSC

12352209

Target

Others

Type

Peptides

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/β-interleukin-i-163-171-human.html

Solubility

10 mM in DMSO

Smiles

NCCCC[C@@H](C(O)=O)NC([C@H](CC(O)=O)NC([C@H](CC(N)=O)NC([C@H](CO)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC(CNC([C@H](CCC(N)=O)NC([C@H](C(C)C)N)=O)=O)=O)=O)=O)=O)=O)=O

Molecular Formula

C39H64N12O19

Molecular Weight

1004.99

References & Citations

[1]Nencioni L, et al. In vivo immunostimulating activity of the 163-171 peptide of human IL-1 beta. J Immunol. 1987 Aug 1;139 (3) :800-4. |[2]Forni G, et al. Ability of a nonapeptide of the human IL-1 beta to recruit anti-tumor reactivity in recipient mice. J Immunol. 1989 Jan 15;142 (2) :712-8. |[3]Boraschi D, , et al. In vivo stimulation and restoration of the immune response by the noninflammatory fragment 163-171 of human interleukin 1 beta. J Exp Med. 1988 Aug 1;168 (2) :675-86. |[4]Tagliabue, A., et al. (1997) . Interleukin 1 and Its Synthetic Peptide 163–171 as Vaccine Adjuvants. Vaccine Design pp 167-173. |[5]Boraschi D, et al. Binding and internalization of the 163-171 fragment of human IL-1 beta. Cytokine. 1992 May;4 (3) :201-4. |[6]Bajpai K, et al. Immunomodulating activity of analogs of noninflammatory fragment 163-171 of human interleukin-1beta. Immunopharmacology. 1998 Jan;38 (3) :237-45.