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CLK1/2-IN-3

LK1/2-IN-3 (compound 3) is a potent and selective CLK1 and CLK2 inhibitor with IC50 values of 1.1, 2.1, 130, 260, 260 nM for CLK1, CLK2, SRPK1, SRPK2, SRPK3, respectively. CLK1/2-IN-3 shows anti-proliferative activity. CLK1/2-IN-3 reduces the levels of endogenous phosphorylated SR proteins and increases the expression of S6K mRNAs[1].

Product Specifications

CAS Number

1005784-60-0

UNSPSC

12352005

Target

CDK; SRPK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/clk1-2-in-3.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CN2C=C(C3=CNN=C3)C=CC2=N1)C4=CC=C(C(C)(C)CO)C=C4

Molecular Formula

C21H21N5O2

Molecular Weight

375.42

References & Citations

[1]Araki S, et al. Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicing. PLoS One. 2015;10 (1) :e0116929. Published 2015 Jan 12.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CLK

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