CLK1/2-IN-3
LK1/2-IN-3 (compound 3) is a potent and selective CLK1 and CLK2 inhibitor with IC50 values of 1.1, 2.1, 130, 260, 260 nM for CLK1, CLK2, SRPK1, SRPK2, SRPK3, respectively. CLK1/2-IN-3 shows anti-proliferative activity. CLK1/2-IN-3 reduces the levels of endogenous phosphorylated SR proteins and increases the expression of S6K mRNAs[1].
Product Specifications
CAS Number
1005784-60-0
UNSPSC
12352005
Target
CDK; SRPK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/clk1-2-in-3.html
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CN2C=C(C3=CNN=C3)C=CC2=N1)C4=CC=C(C(C)(C)CO)C=C4
Molecular Formula
C21H21N5O2
Molecular Weight
375.42
References & Citations
[1]Araki S, et al. Inhibitors of CLK protein kinases suppress cell growth and induce apoptosis by modulating pre-mRNA splicing. PLoS One. 2015;10 (1) :e0116929. Published 2015 Jan 12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CLK
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
