THPN

THPN is a potent Nur77 agonist. THPN specifically binds the LBD of Nur77 (TR3) but not that of retinoic acid receptor α and PPARγ with a Kd of 270 nM. THPN leads to Nur77 translocation to the mitochondria to induce autophagic cell death in melanoma[1][2].

Product Specifications

CAS Number

[100079-26-3]

UNSPSC

12352005

Hazard Statement

H302

Target

Nuclear Hormone Receptor 4A/NR4A

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/thpn.html

Purity

98.00

Solubility

10 mM in DMSO

Smiles

CCCCCCCCC(C1=CC(O)=C(O)C(O)=C1)=O

Molecular Formula

C15H22O4

Molecular Weight

266.33

Precautions

H302

References & Citations

[1]Wei-jia Wang, et al. Orphan nuclear receptor TR3 acts in autophagic cell death via mitochondrial signaling pathway. Nat Chem Biol. 2014 Feb;10 (2) :133-40. |[2]Li Li, et al. Impeding the interaction between Nur77 and p38 reduces LPS-induced inflammation. Nat Chem Biol. 2015 May;11 (5) :339-46.