LY 163443
LY 163443 is a selective antagonist of leukotrienes D4 (LTD4) and E4 (LTE4) . LY 163443 can antagonize LTD4-induced contractions of guinea pig ileum, trachea, and lung parenchyma. LY 163443 also inhibits tracheal contractions to LTE4[1][2].
Product Specifications
CAS Number
97581-70-9
UNSPSC
12352005
Target
Leukotriene Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ly-163443.html
Solubility
10 mM in DMSO
Smiles
CC(C1=CC=C(C(CCC)=C1O)COC2=CC=C(C=C2)CC3=NN=NN3)=O
Molecular Formula
C20H22N4O3
Molecular Weight
366.41
References & Citations
[1]Fleisch JH, et, al. Evaluation of LY163443, 1-[2-hydroxy-3-propyl-4- ([4- (1H-tetrazol-5-ylmethyl) phenoxy]methyl) phenyl]ethanone, as a pharmacologic antagonist of leukotrienes D4 and E4. Naunyn Schmiedebergs Arch Pharmacol. 1986 May;333 (1) :70-7. |[2]Bitterman H, et, al. Use of a novel peptide leukotriene receptor antagonist, Ly-163443, in splanchnic artery occlusion shock. Prostaglandins Leukot Essent Fatty Acids. 1988 May;32 (2) :63-70.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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