MRS2298
MRS2298 is a potent acyclic P2Y1 receptor antagonist with a Ki of 29.6 nM. MRS2298 inhibits the ADP-induced aggregation of human platelets with an IC50 of 62.8 nM. MRS2298 inhibits Ca2+ rise in platelets with an IC50 of 810 nM[1].
Product Specifications
CAS Number
491611-43-9
UNSPSC
12352005
Target
P2Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mrs2298.html
Solubility
10 mM in DMSO
Smiles
O=P(OCC(COP(O)(O)=O)CN1C=NC2=C(N=C(N=C12)Cl)NC)(O)O
Molecular Formula
C10H16ClN5O8P2
Molecular Weight
431.66
References & Citations
[1]Marco Cattaneo, et al. Antiaggregatory activity in human platelets of potent antagonists of the P2Y 1 receptor. Biochem Pharmacol. 2004 Nov 15;68 (10) :1995-2002.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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