A-933548

A-933548 is a potent and selective inhibitor of calpain, with a Ki of 18 nM. A-933548 can be used for the research of Alzheimer's disease[1].

Product Specifications

CAS Number

[1037826-43-9]

UNSPSC

12352005

Target

Proteasome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/a-933548.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(N=CC=C1)N2N=C(C=C2)C3=CC=CC=C3)NC(CC4=CC=CC=C4)C(C(N)=O)=O

Molecular Formula

C25H21N5O3

Molecular Weight

439.47

References & Citations

[1]Kling A, et, al. Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2- (3-Phenyl-1H-pyrazol-1-yl) -nicotinamides. J Med Chem. 2017 Aug 24;60 (16) :7123-7138.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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