Asimicin
Product Specifications
UNSPSC Description
Asimicin (Bullatacin) is antitumor acetogenin that can be isolated from the bark and seeds of the pawpaw tree, Asimina trilobal Dunal. Asimicin inhibits mitochondrial respiration through the inhibition of complex I. Asimicin shows toxicity to Aphis gossypii, mosquito larvae and mammalian[1][2][3][4].
Target Antigen
Mitochondrial Metabolism; Parasite
Type
Reference compound
Related Pathways
Anti-infection;Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/asimicin.html
Solubility
10 mM in DMSO
Smiles
O=C1O[C@H](C=C1C[C@@H](CCCCCCCCCC[C@H]([C@H]2CC[C@@H](O2)[C@@H]3O[C@H](CC3)[C@@H](CCCCCCCCCC)O)O)O)C
Molecular Weight
622.92
References & Citations
[1]Kawamata T, et al. Convergent Total Synthesis of Asimicin via Decarbonylative Radical Dimerization. Chemistry. 2018 Dec 17;24(71):18907-18912.|[2]Zhao GX, et al. Asimin, asiminacin, and asiminecin: novel highly cytotoxic asimicin isomers from Asimina triloba. J Med Chem. 1994 Jun 24;37(13):1971-6.|[3]Ligang Zhou, et al. Secondary Metabolites with Antinematodal Activity from Higher Plants. Studies in Natural Products Chemistry. Volume 37, 2012, Pages 67-114.|[4]E. David Morgan and Ian D. Wilson. Insect Hormones and Insect Chemical Ecology. Comprehensive Natural Products Chemistry. Volume 8, 1999, Pages 263-375.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-113607/Asimicin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-113607/
Clinical Information
No Development Reported
CAS Number
102989-24-2
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