Asimicin

Product Specifications

CAS Number

[102989-24-2]

UNSPSC Description

Asimicin (Bullatacin) is antitumor acetogenin that can be isolated from the bark and seeds of the pawpaw tree, Asimina trilobal Dunal. Asimicin inhibits mitochondrial respiration through the inhibition of complex I. Asimicin shows toxicity to Aphis gossypii, mosquito larvae and mammalian[1][2][3][4].

Target Antigen

Mitochondrial Metabolism; Parasite

Type

Reference compound

Related Pathways

Anti-infection;Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/asimicin.html

Solubility

10 mM in DMSO

Smiles

O=C1O[C@H](C=C1C[C@@H](CCCCCCCCCC[C@H]([C@H]2CC[C@@H](O2)[C@@H]3O[C@H](CC3)[C@@H](CCCCCCCCCC)O)O)O)C

Molecular Weight

622.92

References & Citations

[1]Kawamata T, et al. Convergent Total Synthesis of Asimicin via Decarbonylative Radical Dimerization. Chemistry. 2018 Dec 17;24(71):18907-18912.|[2]Zhao GX, et al. Asimin, asiminacin, and asiminecin: novel highly cytotoxic asimicin isomers from Asimina triloba. J Med Chem. 1994 Jun 24;37(13):1971-6.|[3]Ligang Zhou, et al. Secondary Metabolites with Antinematodal Activity from Higher Plants. Studies in Natural Products Chemistry. Volume 37, 2012, Pages 67-114.|[4]E. David Morgan and Ian D. Wilson. Insect Hormones and Insect Chemical Ecology. Comprehensive Natural Products Chemistry. Volume 8, 1999, Pages 263-375.