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Erbstatin

Erbstatin, a EGFR kinase inhibitor, possesses antineoplastic effect[1][2].

Product Specifications

CAS Number

100827-28-9

UNSPSC

12352005

Target

Apoptosis; EGFR

Type

Reference compound

Related Pathways

Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/erbstatin.html

Solubility

10 mM in DMSO

Smiles

O=CN/C=C/C1=CC(O)=CC=C1O

Molecular Formula

C9H9NO3

Molecular Weight

179.17

References & Citations

[1]Shigeki Kobayashi, et al. Diastereomer-specific effects of double-stranded peptides conjugated with -L-Tyr-L-Phe- or -L-Tyr-D-Phe- residues on tyrosine phosphorylation and inhibition of src (ts) NRK, A431, MCF-7, and DU145 cell growth. Chem Pharm Bull (Tokyo) . 2007 Nov;55 (11) :1585-92.|[2]M Toi, et al. Antineoplastic effect of erbstatin on human mammary and esophageal tumors in athymic nude mice. Eur J Cancer. 1990;26 (6) :722-4.|[3]S Simizu, et al. Involvement of hydrogen peroxide production in erbstatin-induced apoptosis in human small cell lung carcinoma cells. Cancer Res. 1996 Nov 1;56 (21) :4978-82.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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