Erbstatin
Erbstatin, a EGFR kinase inhibitor, possesses antineoplastic effect[1][2].
Product Specifications
CAS Number
100827-28-9
UNSPSC
12352005
Target
Apoptosis; EGFR
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/erbstatin.html
Solubility
10 mM in DMSO
Smiles
O=CN/C=C/C1=CC(O)=CC=C1O
Molecular Formula
C9H9NO3
Molecular Weight
179.17
References & Citations
[1]Shigeki Kobayashi, et al. Diastereomer-specific effects of double-stranded peptides conjugated with -L-Tyr-L-Phe- or -L-Tyr-D-Phe- residues on tyrosine phosphorylation and inhibition of src (ts) NRK, A431, MCF-7, and DU145 cell growth. Chem Pharm Bull (Tokyo) . 2007 Nov;55 (11) :1585-92.|[2]M Toi, et al. Antineoplastic effect of erbstatin on human mammary and esophageal tumors in athymic nude mice. Eur J Cancer. 1990;26 (6) :722-4.|[3]S Simizu, et al. Involvement of hydrogen peroxide production in erbstatin-induced apoptosis in human small cell lung carcinoma cells. Cancer Res. 1996 Nov 1;56 (21) :4978-82.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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