6-Phosphogluconic acid

6-Phosphogluconic acid is a potent and competitive phosphoglucose isomerase (PGI) inhibitor with Kis of 48 μM for glucose 6-phosphate and 42 μM for fructose 6-phosphate. 6-Phosphogluconic acid is an endogenous metabolite[1][2].

Product Specifications

CAS Number

[921-62-0]

UNSPSC

12352211

Hazard Statement

H302-H312-H332

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/6-phosphogluconic-acid.html

Solubility

10 mM in DMSO

Smiles

OC([C@H](O)[C@@H](O)[C@H](O)[C@H](O)COP(O)(O)=O)=O

Molecular Formula

C6H13O10P

Molecular Weight

276.14

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Gaitonde MK, et al. Effect of 6-phosphogluconate on phosphoglucose isomerase in rat brain in vitro and in vivo. J Neurochem. 1989 May;52 (5) :1348-52.|[2]Hitosugi T, et al. Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 2012 Nov 13;22 (5) :585-600.