Delta-12-Prostaglandin J2

Delta-12-Prostaglandin J2 (Δ12-PGJ2) is a cyclopentenone prostaglandin (PG) with anti-proliferative effect on various tumor cell growth. Delta-12-Prostaglandin J2, a naturally occurring dehydration product of prostaglandin D2, is able to induce apoptosis in HeLa cells via caspase activation[1][2].

Product Specifications

CAS Number

[87893-54-7]

Product Name Alternative

Δ12-PGJ2

UNSPSC

12352211

Hazard Statement

H225-H319-H336

Target

Apoptosis; Endogenous Metabolite

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/delta-12-prostaglandin-j2.html

Concentration

2.99 mM * 100 μL in Methyl acetate

Purity

99.0

Solubility

10 mM in DMSO

Smiles

CCCCC[C@H](O)C/C=C1[C@H](C=CC\1=O)C/C=C\CCCC(O)=O

Molecular Formula

C20H30O4

Molecular Weight

334.45

Precautions

P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P370+P378-P403+P233-P403+P235-P405-P501

References & Citations

[1]Kim BE, et al. Involvement of Sox-4 in the cytochrome c-dependent AIF-independent apoptotic pathway in HeLa cells induced by Delta12-prostaglandin J2. Exp Mol Med. 2004;36 (5) :444-453.