5 (S) 15 (S) -DiHETE
5 (S) 15 (S) -DiHETE is an “activated” intermediate, inhibits platelet aggregation with an IC50 of 1.3 μM. 5 (S) 15 (S) -DiHETE enhances the rate of either LXA4 or LXB4 biosynthesis[1].
Product Specifications
CAS Number
82200-87-1
UNSPSC
12352211
Hazard Statement
H225, H319
Target
Interleukin Related
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/5-s-15-s-dihete.html
Concentration
297.20 μM * 250 μL in Ethanol
Purity
99.0
Solubility
10 mM in DMSO
Smiles
CCCCC[C@H](O)/C=C/C=C\C/C=C\C=C\[C@@H](O)CCCC(O)=O
Molecular Formula
C20H32O4
Molecular Weight
336.47
Precautions
H225, H319
References & Citations
[1]Abigail R Green, et al. 5 S,15 S-Dihydroperoxyeicosatetraenoic Acid (5,15-diHpETE) as a Lipoxin Intermediate: Reactivity and Kinetics with Human Leukocyte 5-Lipoxygenase, Platelet 12-Lipoxygenase, and Reticulocyte 15-Lipoxygenase-1. Biochemistry. 2018 Dec 4;57 (48) :6726-6734.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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