14,15-Epoxyeicosatrienoic acid

14,15-Epoxyeicosatrienoic acid (14,15-EET) is a metabolite of Arachidonic acid (HY-109590) . 14,15-Epoxyeicosatrienoic acid is a potent inhibitor of in vivo platelet aggregation. 14,15-Epoxyeicosatrienoic acid facilitates astrocytic Aβ clearance. 14,15-Epoxyeicosatrienoic acid can be used for Alzheimer's Disease research[1][2].

Product Specifications

CAS Number

[81276-03-1]

Product Name Alternative

14,15-EET

UNSPSC

12352005

Hazard Statement

H225, H319

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/14-15-epoxyeicosatrienoic-acid.html

Concentration

312.04 μM * 500 μL in Ethanol

Purity

99.9

Solubility

10 mM in DMSO

Smiles

O=C(O)CCC/C=C/C/C=C/C/C=C/CC1OC1CCCCC

Molecular Formula

C20H32O3

Molecular Weight

320.47

Precautions

H225, H319

References & Citations

[1]Chen W, et al. 14,15-Epoxyeicosatrienoic Acid Alleviates Pathology in a Mouse Model of Alzheimer's Disease. J Neurosci. 2020 Oct 14;40 (42) :8188-8203.|[2]Heizer ML, et al. 14,15-Epoxyeicosatrienoic acid inhibits platelet aggregation in mouse cerebral arterioles. Stroke. 1991 Nov;22 (11) :1389-93.