20-Carboxy-Leukotriene B4

20-Carboxy-Leukotriene B4 (20-COOH LTB4) is a metabolite of Leukotriene B4 (LTB4; HY-107608) . 20-Carboxy-Leukotriene B4 binds to the BLT1 receptor with high affinity. 20-Carboxy-Leukotriene B4 inhibits LTB4-mediated neutrophil responses (migration, degranulation, leukotriene biosynthesis) [1].

Product Specifications

CAS Number

[80434-82-8]

Product Name Alternative

20-COOH LTB4

UNSPSC

12352211

Hazard Statement

H225-H315-H319-H335

Target

Drug Metabolite; Leukotriene Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/20-carboxy-leukotriene-b4.html

Concentration

272.89 μM * 250 μL in Ethanol

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O=C(O)CCC[C@H](O)/C=C\C=C\C=C\[C@H](O)C/C=C\CCCCC(O)=O

Molecular Formula

C20H30O6

Molecular Weight

366.45

Precautions

P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P362+P364-P370+P378-P403+P233-P403+P235-P405-P501

References & Citations

[1]Anne-Sophie Archambault, et al. 20-Hydroxy- and 20-carboxy-leukotriene (LT) B4 downregulate LTB4 -mediated responses of human neutrophils and eosinophils. J Leukoc Biol. 2019 Jun;105 (6) :1131-1142.