10-Nitrolinoleic acid
10-Nitrolinoleic acid is a potent peroxisome proliferator-activated receptor γ (PPARγ) agonist. 10-Nitrolinoleic acid competes with [3H]Rosiglitazone for binding to PPAR-γ, with an IC50 of 0.22 μM[1].
Product Specifications
CAS Number
[774603-04-2]
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/10-nitrolinoleic-acid.html
Concentration
3.07 mM * 100 μL in Ethanol
Purity
95.0
Solubility
10 mM in DMSO
Smiles
CCCCC/C=C\C/C([N+]([O-])=O)=C\CCCCCCCC(O)=O
Molecular Formula
C18H31NO4
Molecular Weight
325.44
Precautions
H302, H315, H319, H335
References & Citations
[1]Dunny E, et, al. Stereocontrolled synthesis of the PPAR-gamma agonist 10-nitrolinoleic acid. J Org Chem. 2010 Aug 6;75 (15) :5334-6.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARγ
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