Perillic acid

Perillic acid is the metabolite of Perillyl alcohol (HY-N7000) . Perillic acid induces lung cancer cell cycle arrest and apoptosis. Perillic acid shows anti-HSV-1 and immunomodulatory activities[1][2][3].

Product Specifications

CAS Number

[7694-45-3]

UNSPSC

12352211

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; Drug Metabolite; HSV

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/perillic-acid.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CCC(C(C)=C)CC1)O

Molecular Formula

C10H14O2

Molecular Weight

166.22

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Yeruva L, et al. Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells. Cancer Lett. 2007 Nov 18;257 (2) :216-26.|[2]Mello CP, et al. Perillyl alcohol and perillic acid exert efficient action upon HSV-1 maturation and release of infective virus. Antivir Ther. 2020;25 (1) :1-11.|[3]Raphael TJ, et al. Immunomodulatory activity of naturally occurring monoterpenes carvone, limonene, and perillic acid. Immunopharmacol Immunotoxicol. 2003 May;25 (2) :285-94.